Projects


7T-MRI neurofeedback for treatment-resistant depression
Active
A feasibility study and randomized controlled trial (>200 patients) of advanced neurofeedback using high-resolution 7T MRI in treatment-resistant depression.
2025-2027 ·Matter Neuroscience Inc.
Manish Saggar Niharika Gajawelli Conor Vedova
With: Cammie Rolle, David Spiegel
Data-driven validation of the NIMH RDoC framework
Active
A large-scale, data-driven test of the hierarchical structure of the NIMH RDoC framework using datasets such as ABCD.
2021-2026 ·NIMH
Manish Saggar Shaun K.L. Quah Saad Pirzada Cameron Glick Young-Eun Lee
With: Booil Jo, Russ Poldrack, Ian Gotlib, Jeanette Mumford, Deanna Barch, Damien Fair, Lucina Uddin
Quantifying changes in brain dynamics associated with non-invasive brain stimulation
Active
Developing computational methods to quantify changes in brain dynamics induced by non-invasive brain stimulation (TMS).
2020-2026 ·NIMH
Manish Saggar Yinming Sun Niharika Gajawelli
With: Nolan Williams, David Spiegel, Amit Etkin, Corey Keller, Cammie Rolle
Computational Mitochondrial PsychoBiology
Completed
A pilot led by Dr. Martin Picard (Columbia) developing computational methods to capture communication dynamics between mitochondria.
2021-2025 ·Philanthropic support
Manish Saggar
With: Martin Picard (lead, Columbia)
Examining the neural basis of applied creativity in entrepreneurs
Completed
Comparing the brain structure and function of entrepreneurs versus managers to uncover the neural basis of applied creativity in business.
2019-2020 ·HPDTRP, Stanford
Manish Saggar Sahar Jahanikia Caleb Geniesse Hua (Oliver) Xie Katerina D. Monlux Alexa Booras
With: Neeraj Sonalkar, Jan Auernhammer
Only time will tell - a computational psychiatry approach to model temporal transitions in brain activity as a lens towards developing better diagnostic nosology for psychiatric illness
Completed
Modeling the full landscape of the brain's dynamical organization at the individual level, as a lens for characterizing and stratifying psychiatric illness.
2018-2023 ·New Innovator Award (DP2), NIMH
Manish Saggar Samir Chowdhury Caleb Geniesse Sahar Jahanikia Mengsen Zhang Hua (Oliver) Xie Kaitlin Maile Yinming Sun Niharika Gajawelli Alexa Booras Shaun K.L. Quah
Understanding the role of design reflection (vs rumination) in creative thinking
Completed
A cross-disciplinary study (neuroscience, design interaction, speech analysis) quantifying design reflection versus rumination in creative thinking.
2017-2018 ·HPDTRP, Stanford
Manish Saggar Sahar Jahanikia Caleb Geniesse Hua (Oliver) Xie
With: Neeraj Sonalkar
Deciphering “ongoing” cognition using concurrent multimodal neuroimaging and continuous multitask paradigm
Completed
Combining simultaneous EEG-fMRI with a continuous multitask paradigm to link moment-to-moment functional-connectivity dynamics to ongoing cognition.
2016-2018 ·Department Innovator Award, Stanford
Manish Saggar Amber Howell Sahar Jahanikia Caleb Geniesse Yinming Sun
Quantifying and capturing transitions in intrinsic brain activity in healthy and patient populations
Completed
Developing individualized metrics to capture and computationally model resting-state brain dynamics, toward personalized biomarkers for mental illness.
2015-2020 ·NIMH (K99/R00)
Manish Saggar Sahar Jahanikia Amber Howell Atanas D. Stankov
With: Allan Reiss, Gunnar Carlsson, Olaf Sporns
Creative brain development
Completed
Using fNIRS in 3rd- and 4th-graders to understand how the creative brain develops and why creative capacity often dips in 4th grade.
2013-2014 ·MCHRI, Stanford
Manish Saggar Meredith Schreier
With: Allan Reiss
Examining the neural correlates of creative capacity enhancement using targetted training.
Completed
Testing whether creative capacity can be enhanced through targeted training, and mapping the accompanying changes in brain dynamics.
2011-2016 ·HPDTRP, Stanford
Manish Saggar
With: Grace Hawthorne, Allan Reiss
Brain dynamics associated with intensive meditation training
Completed
Characterizing and computationally modeling the longitudinal EEG changes from ~3 months of intensive meditation training, as part of the larger Shamatha Project.
2006-2011 ·Mind & Life Institute (Varela Award)
Manish Saggar
With: Clifford Saron, Risto Miikkulainen