Aims
Transcranial Magnetic Stimulation (TMS) facilitates controlled, non-invasive, modulation of the brain by modifying local brain activity and has the potential to examine recruitment, activation and coordination of cortical networks in health and disease. To optimize the application of TMS, e.g., for precision medicine, it is important to first carefully characterize the stimulation-induced changes in spatiotemporal dynamics. To this end, using concurrent TMS-fMRI(EEG), we are examining stimulation-induced changes in brain dynamics and functional organization associated different stimulation sites.
Highlights
- Examining changes in functional re-organization associated with single-pulse and rTMS
- Examining changes in temporal re-organization associated with single-pulse and rTMS
- Developing biophysical network models to simulate the effects of TMS
Funding
NIMH
Papers from this project
Neurophysiological signatures of Stanford Neuromodulation Therapy in treatment resistant depression
Momi D., Buchanan D., Wada M., Geoly A.D., Johnson N.J., Cole E.J., Maron-Katz A., Tischler C., Cline C.C., Saggar M., Voineskos D., Griffiths J.D., Rolle C.E., Keller C.J., Williams N. medRxiv (2025)
Momi D., Buchanan D., Wada M., Geoly A.D., Johnson N.J., Cole E.J., Maron-Katz A., Tischler C., Cline C.C., Saggar M., Voineskos D., Griffiths J.D., Rolle C.E., Keller C.J., Williams N. medRxiv (2025)
Concurrent single-pulse TMS-fMRI dataset to reveal the causal connectome in healthy and patient populations
Glick C., Gajawelli N., Sun Y., Badami F., Saggar M. Etkin A. Scientific Data (2025)
Glick C., Gajawelli N., Sun Y., Badami F., Saggar M. Etkin A. Scientific Data (2025)
Excitation-Inhibition Balance and Fronto-Limbic Connectivity Drive TMS Treatment Outcomes in Refractory Depression
Momi D., Wang Z., Oveisi M.P., Kadak K., Bastiaens S.P., Lissemore J.I., Noda Y., Downar J., Rodriguez F.V., Strafella R., Daskalakis Z.J., Zrenner C., Zomorrodi R., Rolle C.E., Saggar M., Williams N., Keller C.J., Blumberger D.M., Voineskos D., Griffiths J.D. BioRxiv (2025)
Momi D., Wang Z., Oveisi M.P., Kadak K., Bastiaens S.P., Lissemore J.I., Noda Y., Downar J., Rodriguez F.V., Strafella R., Daskalakis Z.J., Zrenner C., Zomorrodi R., Rolle C.E., Saggar M., Williams N., Keller C.J., Blumberger D.M., Voineskos D., Griffiths J.D. BioRxiv (2025)
Increased anti-correlation between the left dorsolateral prefrontal cortex and the default mode network following Stanford Neuromodulation Therapy (SNT) analysis of a double-blinded, randomized, sham-controlled trial
Gajawelli N., Geoly A. D., Batail JM, Xiao X., Maron-Katz A., Cole E., Azeez A., Kratter I.H., Saggar M., Williams N.R. Mental Health Research (2024)
Gajawelli N., Geoly A. D., Batail JM, Xiao X., Maron-Katz A., Cole E., Azeez A., Kratter I.H., Saggar M., Williams N.R. Mental Health Research (2024)
Densely sampled stimulus-response map of human cortex with single pulse TMS-EEG and its relation to whole brain neuroimaging measures
Sun Y., Lucas M. V., Cline C. C., Menezes M. C., Kim S., Badami F. S., Narayan M., Wu W., Daskalakis Z. J., Etkin A., Saggar M. BioRxiv (2024)
Sun Y., Lucas M. V., Cline C. C., Menezes M. C., Kim S., Badami F. S., Narayan M., Wu W., Daskalakis Z. J., Etkin A., Saggar M. BioRxiv (2024)
Network effects of Stanford Neuromodulation Therapy (SNT) in treatment-resistant major depressive disorder a randomized, controlled trial
Batail J.M., Xiao X., Azeez A., Tischler C., Kratter I.H., Bishop J.H., Saggar M., Williams N.R. Translational Psychiatry (2023)
Batail J.M., Xiao X., Azeez A., Tischler C., Kratter I.H., Bishop J.H., Saggar M., Williams N.R. Translational Psychiatry (2023)